Molecular Response After Concurrent Exercise With Low Glycogen (Glyconcurrent)

Wageningen University

Status

Completed

Conditions

Healthy

Treatments

Other: Standard meal containing low or high carbohydrate content

Study type

Interventional

Funder types

Other

Identifiers

NCT02668445

NL54408.081.15

Details and patient eligibility

About

This is a randomized, counterbalanced crossover design, in which 14 male subjects will complete two experimental trials. Each trial will be separated by a minimum of at least 12 days (range: 12-30 days). The study aims to investigate the effects of low glycogen availability on skeletal muscle molecular response after a concurrent exercise day.

Full description

Two experimental exercise trials; a low carbohydrate (= LOW) and a high carbohydrate (= HIGH) trial. During both experimental days subjects will complete an continues submaximal cycling bout in the morning followed by a resistance exercise session in the early afternoon. During the LOW trial subjects will receive a low carbohydrate mixed meal, during the HIGH trial subjects will be provided with a high carbohydrate meal. In addition, on both experimental days subjects will receive adequate protein beverages. Lastly, protein will be provided post resistance exercise.

Enrollment

14 patients

Sex

Male

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male gender between 18 and 30 years of age
BMI between 18.5 - 25 kg/m2
Participating in regular exercise training (at least 1 exercise session, and a maximum of 3 exercise session per week)
Used to different types of exercise (endurance, resistance and/or concurrent)
Willing to give blood samples
Willing to give muscle biopsies
No use of antibiotics during the study or in the past month
No drug use
Suitable veins for blood withdrawal
Registered by a general-practitioner
Consumption of alcohol beverages is less than 21 per week
No blood donor during the study
No vegetarian and willing to eat meat during the experimental days
Able to be present and participate at both test days and pre testing moments
Not employed, or intern, or working on thesis at the department of Human Nutrition at Wageningen University
Not participating in another scientific study (except EetMeetWeet)
Able to participate during the experimental days en pre tests
Able to speak Dutch

Exclusion criteria

Medical condition that can interfere with the study outcome (i.e. cardiovascular disease, pulmonary disease, gluten intolerance)
Systolic blood pressure >160 mmHg and/or diastolic blood pressure >100 mmHg
Use of medications known to interfere with gene expression in the muscles (i.e. statins, fenofibrate)
Use of antithrombotic therapy (marcoumar, sintromitis).
Diagnosed diabetes mellitus type 1 or 2
(Chronic) injuries of the locomotor system that can interfere with the intervention