Molecular Screening for Lynch Syndrome in Denmark

Vejle Hospital

Status: Completed

Conditions: HNPCC; Lynch Syndrome; Colorectal Cancer

Treatments: Other: Observation

Study type: Observational

Funder types: Other

Identifiers

NCT01845753

MS-LS-DK-02

Details and patient eligibility

About

A clinically applicably strategy for molecular screening for Lynch Syndrome is being implemented in Denmark.

Based on sequential analysis with immunohistochemistry and methylation analysis, patients with possible hereditary colorectal cancer are identified. These patients are offered genetic risk assessment and counselling.

The study hypothesis is that molecular screening will identify more patients with Lynch Syndrome than the family history alone.

Prospective data collection is performed using established clinical databases.

Enrollment: 5,000 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histological diagnosis of colorectal adenocarcinoma
• Diagnosed at one of the departments of pathology in Denmark

Exclusion criteria

• None

Trial design

5,000 participants in 1 patient group

All colorectal cancer patients

Treatment:

Other: Observation