Molecular Screening for Lynch Syndrome in Southern Denmark

Vejle Hospital

Status: Completed

Conditions: HNPCC; Lynch Syndrome; Colorectal Cancer

Treatments: Other: Observation

Study type: Observational

Funder types: Other

Identifiers

NCT01216930

MS-LS-DK-01

10-5156 (Other Grant/Funding Number)

Details and patient eligibility

About

A clinically applicably strategy for molecular screening for Lynch Syndrome has been implemented in the Region of Southern Denmark.

Based on sequential analysis with immunohistochemistry and methylation analysis, patients with possible hereditary colorectal cancer are identified. These patients are offered genetic risk assessment and counselling.

The study hypothesis is that molecular screening will identify more patients with Lynch Syndrome than the family history alone.

Prospective data collection is performed using established clinical databases.

Enrollment: 2,000 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histological diagnosis of colorectal adenocarcinoma
• Diagnosed at one of the five departments of pathology in the region

Exclusion criteria

• None

Trial design

2,000 participants in 1 patient group

All colorectal cancer patients

Treatment:

Other: Observation