Monitoring Exhaled Propofol to Individualize General Anesthesia (EPIGA)

University of California San Francisco (UCSF)

Status and phase: Completed; Phase 1

Conditions: General Anesthesia

Treatments: Drug: Propofol Anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT01191021

H54427-35579

Details and patient eligibility

About

This trial investigates the relationship between concentrations of the anesthetic drug propofol in exhaled breath, blood and drug effect in volunteers undergoing general anesthesia. The main goal of this study is to develop a pharmacokinetic - and dynamic model for propofol in exhaled breath.

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years of age

  • Written informed consent
  • Ability and willingness to give written informed consent
  • American Society of Anesthesiologists (ASA) risk score I

Exclusion criteria

• Volunteers ASA physical status II - III
• Pregnancy
• Volunteers with history of neurological disease or stroke
• Volunteers with a history of recreational drug abuse
• Volunteers with a history of alcohol abuse
• Smokers
• Anesthesia within 6 months
• Known drug allergies
• History of adverse events during general anesthesia

Trial design

20 participants in 1 patient group

Propofol

Other group

Description:

Volunteers will receive propofol anesthesia on the study day.

Treatment:

Drug: Propofol Anesthesia