Monitoring of Hydration Status in Chronic Hemodialysis Patients

Medical University of Lodz

Status: Completed

Conditions: Kidney Failure; Hemodialysis; Overhydration

Treatments: Procedure: dialysisis with and without glucose in the dialysis

Study type: Interventional

Funder types: Other

Identifiers

NCT06798272

163/20

Details and patient eligibility

About

Background Maintaining fluid balance is one of major challenges of the dialysis therapy. It includes, in particular, the management of "dry body mass". We postulated that simple measurement of subscapular skinfold thickness before and after hemodialysis could help monitor hydration status in chronic dialysis patients.

Aim of the study The aim of the study was to compare the conventional methods of monitoring hydration status during hemodialysis with an assessment of skin fold thickness.

Materials and Methods 50 participants (21 F, 29 M; age 60 ±15 years) were enrolled. Directly before the hemodialysis session the following parameters were measured: body composition with bioimpedance spectroscopy, skinfold thickness in subscapular area with standardized caliper and blood tests: blood count, urea, n-terminal pro B-type natriuretic peptide (nt-proBNP) and pro-adrenomedullin (pro-ADM). The procedures were repeated at the end of three consecutive hemodialysis sessions.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic hemodialysis for at least 3 months

Exclusion criteria

• severe mental disabilities, poor compliance, any acute infection, instability of the cardiovascular hemodynamic condition

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

changes of overhydration during hemodialysis session

Experimental group

Treatment:

Procedure: dialysisis with and without glucose in the dialysis