Monitorings the Physiological Mechanism of Airway Pressure Release Ventilation in ARDS Patients by EIT

Huazhong University of Science and Technology

Status: Enrolling

Conditions: Electrical Impedance Tomography; ARDS

Study type: Observational

Funder types: Other

Identifiers

NCT05406427

EIT20220109

Details and patient eligibility

About

Effects of airway pressure release ventilation on pulmonary ventilation, shunt and perfusion in patients with ARDS

Full description

Effects of airway pressure release ventilation on respiratory mechanisms including ventilation distribution, intrapulmonary shunt and V/Q match in lungs of ARDS evaluated by EIT at different time points.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 18 years old < age < 80 years old
2. Diagnosed as moderate or severe ARDS according to the Berlin 2014 definition
3. Predicted APRV mechanical ventilation for more than 72 hours

Exclusion criteria

Excluded if any of the following exclusion criteria are met:

1. APRV contraindications such as pneumothorax, severe chronic obstructive pulmonary disease, severe asthma, intracranial hypertension
2. Pregnant women
3. Severe cardiac dysfunction (New York Heart Association class III or IV, acute coronary syndrome or sustained ventricular tachyarrhythmia), right heart enlargement due to chronic cardiopulmonary disease, cardiogenic shock or cardiac hand
4. Refractory shock
5. BMI>35

Trial design