Monocyte Chemoattractant Protein-1 2518A/G Polymorphism (MCP-1)

Harbin Medical University

Status: Completed

Conditions: Diabetic Retinopathy

Study type: Observational

Funder types: Other

Identifiers

NCT02077127

dongli

Details and patient eligibility

About

The pathogenesis of proliferative diabetic retinopathy (PDR) remains poorly understood. Recent studies have implicated that monocyte chemoattractant protein-1 (MCP-1) is associated with diabetic microvascular or macrovascular complications. However, the relationship between SNP polymorphism c.2518A/G in the MCP-1 gene with diabetic retinopathy remains controversial. In the present study, we evaluated the association of a single nucleotide polymorphism (SNP) in the MCP-1 gene with diabetic retinopathy (DR) and diabetic macular edema (DME) in Chinese population from Southern China with type 2 diabetes.

Full description

The association between polymorphism of MCP-1 c.2518A/G and DR had been reported in Japan and Korea, but their opinion were inconsistent. However there is no report in China so far. This study was designed to clarify the relationship of polymorphism of MCP-1 c.2518A/G with type 2 diabetes with or without DR. The relationship between MCP-1 c.2518A/G and different stage of DR has also been studied.This article proved that the MCP-1 c.2518G/G genotype is a susceptibility gene for DR in Chinese type 2 diabetic patients, especially the High-risk PDR. There is no association with DME and c.2518G/G.

Enrollment: 1,043 patients

Sex: All

Ages: 41 to 68 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetic retinopathy
• age at diagnosis ≥30 years and a known duration of diabetes of ≥5 years.

Exclusion criteria

• eyeball atrophy
• epimacular membrane
• age-related macular degeneration (ARMD)
• intravitreal injection medicine
• vitreous hemorrhage