Monosodium Glutamate on Gastric Emptying

Veronica Beatriz Busoni

Status: Withdrawn

Conditions: Delayed Gastric Emptying

Treatments: Dietary Supplement: Monosodium glutamate

Study type: Interventional

Funder types: Other

Identifiers

NCT02745028

2404

Details and patient eligibility

About

Children with a radionuclide gastric emptying test with abnormal results will undergo a second test with the addition of a weight adjusted dose of monosodium glutamate. The purpose of the study is to determine if a single dose of monosodium glutamate can shorten the gastric emptying time.

Full description

There is evidence that monosodium glutamate has effects on synapsis at the gastric and duodenum level that results in stimulation of contractility resulting on increase rate of gastric emptying. The purpose of the study is to demonstrate that the administration of a single dose of monosodium glutamate can shorten the gastric emptying time.

Patients with a prior study indicating a delay of gastric empting time, will undergo a second test with the addition of a weight adjusted dose of monosodium glutamate. Each patient will serve as her/his own control. Results will be analysed by pair-T test.

Sex: All

Ages: 12 months to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children with delayed gastric emptying not receiving prokinetic medication in the last 72 hours

Exclusion criteria

• Prior gastrointestinal surgery, patients with known history of reaction to monosodium glutamate. History of neoplasia, autoimmune or inflammatory bowel disease.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

With monosodium glutamate

Other group

Description:

Results of one time gastric emptying study with a single dose of monosodium glutamate; 1 g for weight greater than 45 kg, 700mg between 35 and 44,900 kg, 600mg between 25 and 34,900, 500mg between 15 and 25 kg and 250mg in less than 15 kg

Treatment:

Dietary Supplement: Monosodium glutamate