Monthly Versus Two Doses of Ante-Natal Intermittent Preventive Treatment With Sulphadoxine-Pyrimethamine

University College Hospital, Ibadan

Status and phase

Unknown

Phase 1

Conditions

Malaria

Treatments

Drug: Sulphadoxine-pyrimethamine

Study type

Interventional

Funder types

Other

Identifiers

NCT03599596

UCHIbadan

Details and patient eligibility

About

Randomized controlled prospective comparative study

Full description

This study is intended to be a randomized controlled comparative study conducted to compare the effect of monthly versus two doses of ante-natal intermittent preventive treatment with sulphadoxine-pyrimethamine

Enrollment

136 estimated patients

Sex

Female

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Pregnant women
Gestational age between 16 and 28weeks.
No history of use of sulphadoxine-pyrimethamine prior to recruitment
Not on any medication for prophylaxis

Exclusion criteria

Anaemia
HIV positive women
Pre-existing medical conditions e.g diabetes mellitus, haemoglobinopathy, hypertension, kidney disease, heart disease, any endocrine disorder like hypo/hyperthyroidism, Cushing' disease, connective tissue disorders like systemic lupus erythematosus, antiphospholipid syndrome or any otherautoimmune disease with poor feto-maternal outcomes in pregnancy.
History of Glucose -6-Phosphate Dehydrogenase (G6PD) deficiency in patient
Allergy to sulphonamides or pyrimethamine.
Non consenting patients
Multiple gestations