Mood Disorders in Multiple Sclerosis Patients (MSMD)

Islamic Azad University, Tehran

Status: Completed

Conditions: Bipolar Disorder; Unipolar Depression; Mood Disorders; Multiple Sclerosis (MS)

Study type: Observational

Funder types: Other

Identifiers

NCT06652308

MSMood2024-SDU

Details and patient eligibility

About

This study investigates the frequency of unipolar and bipolar mood disorders in patients with multiple sclerosis. MS is a chronic condition that affects the central nervous system, and previous research suggests that mood disorders, such as depression and bipolar disorder, may occur more frequently in MS patients compared to the general population.

A retrospective analysis of 85 patients diagnosed with MS was conducted, evaluating lifetime experiences with mood disorders using structured clinical interviews. The goal is to better understand the prevalence of these mood disorders and to raise awareness of the importance of mental health care in patients with MS. The findings highlight that mood disorders, particularly bipolar disorder, are more common in MS patients than previously thought. This information can help healthcare providers improve screening, diagnosis, and treatment for MS patients suffering from mood disorders.

Full description

This study is a retrospective cohort analysis designed to examine the lifetime prevalence of unipolar and bipolar mood disorders in patients with multiple sclerosis. MS is a chronic, demyelinating condition of the central nervous system that leads to varying degrees of neurological impairment. Previous studies have shown that mood disorders, particularly depression and bipolar disorder, are more prevalent in patients with MS than in the general population.

Data from 85 patients (45 females and 40 males) diagnosed with MS were analyzed, focusing on psychiatric history through structured clinical interviews. The study evaluated the presence of mood disorders, including major depressive disorder, bipolar disorder types I and II, dysthymia, and unclassified mood disorders. Data were collected using DSM-IV criteria to ensure consistency in diagnosis.

The results demonstrate that mood disorders, especially bipolar disorder, are more frequent than previously reported in this patient population. These findings underscore the need for improved mental health screening and treatment for MS patients, as managing psychiatric comorbidities can significantly enhance overall quality of life. The study emphasizes the importance of integrating psychiatric care into routine MS management.

Enrollment: 85 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of Multiple Sclerosis: Participants must have a confirmed diagnosis of multiple sclerosis (MS) by a qualified neurologist.
• Age Range: Participants must be between 18 and 65 years of age.
• Informed Consent: Participants must provide informed consent to participate in the study.
• Geographic Location: Participants must reside in Tehran, Iran.

Exclusion criteria

• Other Neurological Disorders: Individuals with a diagnosis of any other neurological disease (e.g., epilepsy, Parkinson's disease) will be excluded.
• Head Trauma: History of head trauma that resulted in impaired consciousness or memory loss.
• Seizures: A history of seizures that could affect mood.
• Substance Dependence: A history of substance dependence as per DSM-IV criteria.
• Other Physical Illnesses: Any systemic or physical diseases that could lead to mood symptoms.

Trial design

85 participants in 1 patient group

Multiple Sclerosis Patients with Mood Disorders