Mood Effects of Serotonin Agonists

The University of Chicago

Status and phase: Completed; Phase 1

Conditions: Healthy

Treatments: Drug: Lysergic Acid Diethylamide

Study type: Interventional

Funder types: Other

Identifiers

NCT03790358

15-1311

Details and patient eligibility

About

The purpose of this study is to determine the effects of very low doses of serotonergic agonists on depressed mood in human volunteers.

Enrollment: 80 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• English fluency
• High school level education
• BMI between 19 and 30

Exclusion criteria

• Diagnosed medical condition
• women who are nursing, pregnant, or plan to become pregnant within 3 months
• History of psychotic disorder or family history of psychotic disorder

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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80 participants in 4 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Placebo

Treatment:

Drug: Lysergic Acid Diethylamide

low dose MDMA

Experimental group

Description:

6.5ug dose of serotonin agonist

Treatment:

Drug: Lysergic Acid Diethylamide

medium dose

Experimental group

Description:

13ug dose of serotonin agonist

Treatment:

Drug: Lysergic Acid Diethylamide

high dose

Experimental group

Description:

26ug dose of serotonin agonist

Treatment:

Drug: Lysergic Acid Diethylamide