Mood Effects of Serotonin Agonists Extended (MESA-E)

The University of Chicago

Status and phase: Completed; Phase 1

Conditions: Healthy

Treatments: Drug: Serotonin agonist - 26ug; Drug: Serotonin agonist - 13ug; Drug: Placebo

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03934710

IRB18-1183

5R01DA002812 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

In this study we are examining the effects of repeated very low doses of serotonin agonists on mood individuals with negative mood.

Full description

Here, we are examining the effects of four repeated low doses of lysergic acid diethylamide (LSD), compared to placebo, administered to healthy adults at 3-4 day intervals, on mood, cognitive performance and responses to emotional tasks

Enrollment: 56 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• English fluency
• High school level education
• BMI between 19 and 30

Exclusion criteria

• Diagnosed medical condition
• women who are nursing, pregnant, or plan to become pregnant within 3 months
• History of psychotic disorder or family history of psychotic disorder

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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56 participants in 3 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Placebo

Treatment:

Drug: Placebo

Serotonin agonist 13ug

Experimental group

Description:

13ug of serotonin agonist

Treatment:

Drug: Serotonin agonist - 13ug

Serotonin agonist 26ug

Experimental group

Description:

26ug of serotonin agonist

Treatment:

Drug: Serotonin agonist - 26ug