Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?

Memorial University of Newfoundland

Status: Not yet enrolling

Conditions: Sleeve Gastrectomy; Osteoarthritis of Knee; Arthroplasties, Knee Replacement

Treatments: Procedure: laparoscopic sleeve gastrectomy; Procedure: total knee arthroplasty

Study type: Interventional

Funder types: Other

Identifiers

NCT06767787

HREB Application No. 38151

Details and patient eligibility

About

The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery. Our secondary goal is to compare complication rates between these groups to determine if there is a difference based on the order of the two procedures.

Participants will be randomly placed in one of two groups, with each undergoing both procedures but in opposite order. Quality of life will be assessed via questionnaires before and between each procedure, and rates of complications will also be documented to compare their rates between groups.

Enrollment: 142 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI > or = 35, on surgical waitlist for a total knee arthroplasty and laparoscopic sleeve gastrectomy

Exclusion criteria

• a history of revision surgery, surgery for neoplastic disease, significant mental illness, ASA class > 3 denoting absence of significant impact of comorbidities, and previous esophagogastric surgery.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

142 participants in 2 patient groups

Sleeve Gastrectomy then Knee Arthroplasty

Active Comparator group

Description:

Participants in this arm will undergo laparoscopic sleeve gastrectomy followed by a total knee arthroplasty at least 1 year following the first procedure.

Treatment:

Procedure: total knee arthroplasty

Procedure: laparoscopic sleeve gastrectomy

Knee Arthroplasty then Sleeve Gastrectomy

Active Comparator group

Description:

Participants in this arm will undergo total knee arthroplasty followed by laparoscopic sleeve gastrectomy at least 1 year following the first procedure.

Treatment:

Procedure: total knee arthroplasty

Procedure: laparoscopic sleeve gastrectomy