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Morphine Analgesia in Patients With Acute Appendicitis

T

Tehran University of Medical Sciences

Status and phase

Completed
Phase 4

Conditions

Appendicitis

Treatments

Drug: Morphine

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.

Full description

Analgesic administration for pain control in patients with acute abdominal pain, regarding acute appendicitis, is controversial. Despite the results previous studies indicating the safeness of analgesic use in ED for acute abdominal pain, physicians still prefer to postpone their use after performing surgical evaluations. Since many patients admitted to ED are unlikely to receive prompt surgical consultation, many of them need pain relief to prevent unnecessary suffering. On the other hand such pain relief must not interfere with the diagnosis and treatment of patients and do not cause any complications. Morphine is a common and effective analgesic which, if shown to have no effect on correct diagnosis of acute abdomen, can be used for this purpose.

Thus we evaluated morphine effect on pain reduction and diagnostic accuracy in patients admitted to ED with the diagnosis of acute appendicitis.

Enrollment

71 patients

Sex

All

Ages

13 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • clinical signs of acute appendicitis
  • planned for appendectomy
  • supposed to wait for at least 1 hour in the ED before operation

Exclusion criteria

  • suspicion to perforated appendicitis
  • being under the age of 13
  • pregnancy (according to history and ß-HCG result)
  • opium addiction
  • systolic blood pressure of less than 90 mmHG
  • known cases of chronic obstructive pulmonary disease (COPD)
  • known sensitivity to morphine
  • history of sickle cell disease
  • self administration of analgesics before enrollment
  • refusal to participate

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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