Most Effective Stimulation Site in Transcranial Direct Current Stimulation for Gait Recovery After Stoke

Samsung Medical Center

Status: Completed

Conditions: Stroke; Gait Disorders, Neurologic

Treatments: Device: Ipsilesional stimulation; Other: Walking on treadmill; Device: Contralesional stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03460886

2017-11-080

Details and patient eligibility

About

The aim of this study is to investigate the most effective stimulation site in transcranial direct current stimulation for gait recovery after stroke. All subjects will go through four conditions of transcranial direct current stimulation with for 30 minutes. Four conditions are 1) bihemispheric stimulation - anodal stimulation on both ipsilesional and contralesional leg area of primary motor cortex and supplementary motor area. 2) ipsilesional stimulation - anodal stimulation on ipsilesional leg area of primary motor cortex and supplementary motor area. 3) contralesional stimulation - anodal stimulation on contralesional leg area of primary motor cortex and supplementary motor area. 4) sham stimulation. Subjects will walk on treadmill for 10 minutes during transcranial direct current stimulation. Motor evoked potential and functional evaluations will be done before and after stimulation to measure the changes.

Enrollment: 24 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic stroke patients with 6 months after onset.
• Functional ambulation category ≥ 3

Exclusion criteria

• patients who needs assist in surface level walking
• patients with mini mental status exam score under 9
• patients with implantable electronic device
• metal device inside skull
• history of epilepsy
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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24 participants in 4 patient groups

Bihemispheric stimulation

Experimental group

Description:

1. Anodal stimulation on ipsilesional leg motor primary cortex and supplementary motor area 2. Anodal stimulation on contralesional leg motor primary cortex and supplementary motor area Subject walks on treadmill for 10 minute during stimulation.

Treatment:

Other: Walking on treadmill

Device: Contralesional stimulation

Device: Ipsilesional stimulation

Ipsilesional stimulation

Experimental group

Description:

1. Anodal stimulation on ipsilesional leg motor primary cortex and supplementary motor area 2. Sham on contralesional leg motor primary cortex and supplementary motor area Subject walks on treadmill for 10 minute during stimulation.

Treatment:

Other: Walking on treadmill

Device: Ipsilesional stimulation

Contralesional stimulation

Experimental group

Description:

1. Sham stimulation on ipsilesional leg motor primary cortex and supplementary motor area 2. Anodal stimulation on contralesional leg motor primary cortex and supplementary motor area Subject walks on treadmill for 10 minute during stimulation.

Treatment:

Other: Walking on treadmill

Device: Contralesional stimulation

Sham

Active Comparator group

Description:

1. Sham stimulation on ipsilesional leg motor primary cortex and supplementary motor area 2. Sham stimulation on contralesional leg motor primary cortex and supplementary motor area Subject walks on treadmill for 10 minute during stimulation.

Treatment:

Other: Walking on treadmill