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Staphylococcus aureus (SA) is a significant cause of community and hospital acquired infections. SA is carried by approximately 30% of healthy adults. Similar carriage rates have been reported in very young infants and newborns. Previous studies have suggested that the source of SA carriage in young children is SA carried by their mothers. Possible modes of transmission from mother to child are transmission during passage through a colonized birth canal, through lactation and/or close contact.
We aim to 1) Define the route of transmission between mother and newborn. 2) Assess the dynamics of S. aureus carriage during the first years of life and specifically determine risk factors for becoming a persistent carrier of S. aureus
Full description
Design:
prospective cohort study which will examine the risk of exposure to S. aureus carrier mother on the outcome: S. aureus carriage by newborns following delivery and at discharge.
Setting:
Sheba Medical Center obstetrical unit and nursery Gravid women will be recruited during antenatal visit at the Sheba medical Center, 1-4 weeks prior to labor. Women who will agree to participate and sign an informed consent will be screened for nasal and vaginal carriage of S. aureus. Newborns will be screened on delivery day and on discharge day.
Inclusion criteria:
Exclusion criteria:
Enrollment:
300 consecutive women who are defined as S. aureus carriers (see definitions below).
Screening will include:
Stage I before discharge:
Women - nasal screenings:
A) On recruitment day (~1-4 weeks before labor), B) During hospitalization for delivery. Vaginal screening will be performed during the routine gynecologic examination on delivery day.
Newborns - will be screened A) On birth day, at entrance to the nursery. B) On discharge day. Screening will include nasal nares, umbilical, ear and rectal swabbing on each screening while hospitalized.
Data collection by questionnaires filled by recruited women.
Data collection from medical files of the maternity ward.
Stage II after discharge until age 5 years:
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Inclusion criteria
Exclusion criteria
Enrollment:
300 consecutive women who are defined as S. aureus carriers (see definitions below).
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Central trial contact
Ayala Maayan-Metzger, Prof.; Gili Regev-Yochay, MD
Data sourced from clinicaltrials.gov
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