Motor Evoked Potentials With Modified Facilitation Technique (EP-F)

University Hospital Basel

Status: Completed

Conditions: Multiple Sclerosis

Treatments: Diagnostic Test: MEP using standard facilitation technique; Diagnostic Test: MEP using modified facilitation technique

Study type: Interventional

Funder types: Other

Identifiers

NCT03646929

2017-01893 me18Hardmeier;

Details and patient eligibility

About

Investigating the change in Test- Retest- reliability in healthy individuals when applying a modified easy to use facilitation technique compared to standard facilitation technique and analyzing sensitivity and specificity in patients with multiple sclerosis regarding detection of pathologic results

Enrollment: 81 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for healthy individuals:

• Ability to understand the purpose and risks of the study, provide signed and dated informed consent
• Between 18 and 65 year of age
• No neurologic or psychiatric comorbidity requiring continous treatment
• No previous damage of central nervous System

Inclusion Criteria for patients:

• Ability to understand the purpose and risks of the study, provide signed and dated informed consent
• Between 18 and 65 year of age
• patients with inflammatory diseases of the central nervous system (CNS) or multiple sclerosis appointed for routine MEP diagnostic at the Department of Clinical Neurophysiology, University Hospital Basel

Exclusion Criteria:

• Contraindication for measuring of motoric evoked potentials (MEP): metal implants (pacemaker, stents); known epilepsy oder previous epileptic fit
• Known disease of the peripheral nervous system (polyneuropathy)

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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81 participants in 2 patient groups

healthy individuals and patients with multiple sclerosis

Other group

Description:

MEP in healthy individuals and patients with multiple sclerosis are measured using standard facilitation technique

Treatment:

Diagnostic Test: MEP using standard facilitation technique

patients with multiple sclerosis

Other group

Description:

MEP in patients with multiple sclerosis are measured using modified facilitation technique

Treatment:

Diagnostic Test: MEP using standard facilitation technique

Diagnostic Test: MEP using modified facilitation technique