Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia

Civil Hospices of Lyon

Status: Completed

Conditions: Tetraplegia C6-C7; Tetraplegia C5-C6

Treatments: Procedure: motor imagery

Study type: Interventional

Funder types: Other

Identifiers

NCT02860403

2008-541

Details and patient eligibility

About

Single center, pilot study, to evaluate the influence of Motor Imagery (MI) on functional rehabilitation and cerebral plasticity through the qualitative and quantitative mental practice approach. For this, the investigators will use magnetoencephalography (MEG) but also physiological and behavioral indicators developed by the Laboratoire de la Performance Motrice, Mentale et du Matériel (P3M) of Université Claude Bernard Lyon 1 and its partners.

Enrollment: 16 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-55 years old,
• quadriplegia elicited by spinal cord injury (SCI) at the C5, C5-C6, C6, or C6-C7 level,
• complete infra-lesional motor deficit according to the ASIA impairment scale with finger and forearm flexor muscles paralysis,
• post-traumatic period >6 months (since a motor recovery plateau is usually reached at 6-month post-SCI

Exclusion criteria

• non-stabilized hypertension or pathological autonomic nervous system dysfunction (e.g., orthostatic hypotension),
• cerebral damage and/or cognitive deficit,
• elbow or shoulder joint amplitude restriction, upper limb para-osteoarthropathy,
• participation to another study
• presence of metallic objects within the body incompatible with MEG or functional magnetic resonance imaging (fMRI) recordings.

Trial design

Primary purpose: Supportive Care

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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16 participants in 3 patient groups

C6-C7 patients

Experimental group

Description:

C6-C7 patients able to recover tenodesis grasp.

Treatment:

Procedure: motor imagery

C5-C6 patients

Experimental group

Description:

C5-C6 patients for whom surgery for rehabilitation of an upper limb is indicated with a upper limit of one year after trauma, and after complete clinical and functional evaluation

Treatment:

Procedure: motor imagery

Control group

No Intervention group

Description:

a control group (n=6) matched on age and sex to C6-C7 without medical history or neurological disorder