Motor Language Learning (MOTOLANGUAGE)

Civil Hospices of Lyon

Status: Enrolling

Conditions: Healthy Volunteers

Treatments: Behavioral: Hand; Behavioral: Tool-use

Study type: Interventional

Funder types: Other

Identifiers

NCT03223090

69HCL17_0359

2017-A02144-49 (Other Identifier)

Details and patient eligibility

About

This project pursues the validation of an innovative strategy to boost language learning, based on the benefits derived from sensorimotor training.

The common belief of a rigid brain structure in adult life had to be reconsidered during the last decade. After training, local increase in cerebral cortex volume and thickness, the part of the brain containing neuronal cells and synapses, has been documented. Research has established that brain structures active during training expand while learning and return to baseline afterwards. The transient structural increase is thought to reflect "work in progress" within areas involved in learning, meant to integrate new skills in existing neural circuitries, via strengthening and/or selection of local neuronal connections. My main hypothesis is that other functions, as long as they rely on the activity of the same brain territories, can take advantage of this "work in progress". To use an allegory, imagine the restauration of a building (brain area). It can start after the request of improvements from some of the residents (trained function) and then become the occasion for other tenants (other functions) to see realized also their own wish for improvements. In the end everybody will benefit from the restauration, provided that they all live in the same building and everybody has posed their requests during the "work in progress". Out of the allegory, living in the same building means neural overlap of functions in the brain. The case of motor and linguistic systems represents, from this perspective, a unique opportunity. State-of-the-art research 1) proved the existence, and described the temporal evolution of brain plastic changes during sensorimotor learning, and 2) documented neural overlap and functional interactions of motor and linguistic systems. This posits solid bases for a crucial step forward, gravid of important consequences and applications. This project aims to take this step forward by directly testing the innovative hypothesis that brain changes induced by sensorimotor learning induce benefits for linguistic functions relying on the same brain territories.

Enrollment: 1,111 estimated patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Be aged between 20 and 40 years old
• Give an informed consent by signature
• Be part of the national health security system (registered to the Securité Sociale)
• Be French speaker

Exclusion criteria

• A person presenting an history of neurological, psychiatric or linguistic problems cannot be admitted
• Assumption of psychotropic drugs
• Pregnancy or breast-feeding woman
• A person under legal tutoring
• A person under care in other medical structure for reasons different from those of this research
• A person under administrative or judiciary contention
• A person who is not eligible to a MR-exam according to the relative screening questionnaire cannot be admitted to the experiments including MR acquisitions in the protocol
• A person who is not eligible to a tDC Stimulation according to the relative screening questionnaire cannot be admitted to the experiment including tDCS in the protocol
• A person who is defined as bilingual according to the criteria described above cannot be included in this research.
• A person who studied a musical instrument for more than 3 years or plays it regularly cannot take part to the studies in Objective B1, B2 and B3. This might introduce a confound in the rate of motor learning and relative brain plasticity.
• A person who has already learned or has been regularly exposed to the language L2 and/or to the sign language chosen for the studies in Objective A1 and A2 cannot take part to those studies.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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1,111 participants in 2 patient groups

Tool training group

Experimental group

Description:

Motor training with a tool during max 5 weeks (3 days per week, around 30 minutes per day)

Treatment:

Behavioral: Tool-use

Hand training group

Active Comparator group

Description:

Motor training with the right hand during max 5 weeks (3 days per week, around 30 minutes per day)

Treatment:

Behavioral: Hand