Motor, Non-motor and Genetic Determinants of Progression in Parkinson's Disease: A Mexican Multicenter Cohort Study (ReMePARK)

El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez

Status: Completed

Conditions: Parkinson's Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01865877

182133 (Other Grant/Funding Number)

INNN 35/12

Details and patient eligibility

About

The objective of the study is to assess the effect of motor, non-motor and genetic factors on the progression of Parkinson's disease as well as its impact on complications rates.

A large sample of Mexican subjects with Parkinson's disease attending several referral centers will be included.

Data collected will include disease severity and motor scales, non-motor scales as well as genotyping for monogenic forms of the disease.

Assessments will be performed every 6 months for two years.

Full description

Demographic and clinical data will be collected after obtaining a signed informed consent.

Recruitment will be competitive. Data collected includes age, gender, motor phenotype, age at onset, age at diagnosis, smoking history, family history, antiparkinsonic treatment, other treatments and a complete neurological evaluation.

Enrollment: 550 patients

Sex: All

Ages: 20 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of Parkinson's disease by the United Kingdom Parkinson's disease Society Brain Bank Criteria
• Any gender
• Any Hoehn and Yahr stage
• Written informed consent

Exclusion criteria

• Severe comorbidity that may limit proper neurological evaluation as judged by the investigator
• Subjects with atypical or secondary parkinsonism

Trial design

550 participants in 1 patient group

PD Cohort

Description:

Subjects diagnosed with Parkinson's disease