Motor Training and White Matter in Multiple Sclerosis (MS)

H

Hasselt University

Status

Terminated

Conditions

Multiple Sclerosis

Treatments

Device: tDCS
Behavioral: Bimanual Training

Study type

Interventional

Funder types

Other

Identifiers

NCT01279655
MECU2012-001

Details and patient eligibility

About

In the current study the researchers will firstly investigate whether a bimanual coordination training protocol (20 min/day, for 8 consecutive weeks) correlates with changes in white matter architecture and improved upper-limb functionality in patients with multiple sclerosis. Secondly, the researchers predict that motor learning is more efficient when it is combined with anodal transcranial direct current (tDCS) stimulation on the left primary motor cortex.

Enrollment

60 patients

Sex

All

Ages

18 to 68 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Expanded Disability Status Scale (EDSS) scores between 2 and 6.5
  • Stable MS (no relapse during the last 3 months before study onset)
  • age: between 18 and 68 years

Exclusion criteria

  • Patients with other pathologies associated with peripheral and/or central sensory dysfunction or under psychotropic or antiepileptic medication.
  • Standard TMS/tDCS and MRI exclusion criteria (safety questionnaires)

Trial design

60 participants in 3 patient groups, including a placebo group

tDCS and training
Experimental group
Description:
Transcranial Direct current stimulation (tDCS) is applied together with a bimanual learning task. tDCS is delivered through two gel-sponge electrodes (eldith DC Stimulator, neuroConn GmbH, Ilmenau, Germany) embedded in a saline-soaked solution. tDCS will be applied for 20 min, with a current intensity of 1mA.
Treatment:
Behavioral: Bimanual Training
Device: tDCS
Control
No Intervention group
Description:
No intervention is applied
Sham tDCS + Training
Placebo Comparator group
Description:
The training consists of a bimanual training task. tDCS is only applied for a few seconds and will than be ramped-down.
Treatment:
Behavioral: Bimanual Training
Device: tDCS

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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