Mouse Allergen and Asthma Intervention Trial (MAAIT)

Johns Hopkins University

Status and phase: Completed; Phase 3

Conditions: Asthma; Mouse Allergy; Mouse Allergen Exposure

Treatments: Other: Education; Other: Integrated Pest Management

Study type: Interventional

Funder types: Other

Identifiers

NCT01251224

1U01AI083238

Details and patient eligibility

About

The MAAIT is a randomized, controlled trial of a home intervention to reduce mouse allergen exposure in mouse allergic children with asthma and mouse allergen exposure. Participants will be randomized to either the Integrated Pest Management (IPM) Group or the Education Group. The IPM Group will receive professional mouse abatement, education, two HEPA filters, allergen-proof mattress and pillow encasements, and targeted cleaning. The Education Group will receive education about IPM at the beginning of the trial and then after completion of the trial, will receive the IPM intervention. Participants will be followed for 12 months.

Enrollment: 361 patients

Sex: All

Ages: 6 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• persistent asthma
• exacerbation, previous 12 months
• evidence of mouse sensitization
• high levels of mouse allergen in home
• ages 5-17 years

Exclusion criteria

• intermittent asthma
• no exacerbation in previous 12 months
• not sensitized to mouse
• low or undetectable mouse allergen in home
• other lung disease aside from asthma

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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361 participants in 2 patient groups

Education Group

Active Comparator group

Description:

This group will receive IPM education at baseline, and then the full IPM intervention after completing the study.

Treatment:

Other: Education

IPM Group

Experimental group

Description:

This group will receive the full IPM intervention at baseline.

Treatment:

Other: Integrated Pest Management