Move Study in Healthy Aging People

Nestlé

Status

Completed

Conditions

Joint Pain

Treatments

Behavioral: progressive physical activity

Dietary Supplement: Nutrition intervention, test formula

Study type

Interventional

Funder types

Industry

Identifiers

NCT02276183

13.25 NRC

Details and patient eligibility

About

Bone and muscle losses occur during ageing leading to increased risk of osteoporosis (there are more than 200 million people affected by osteoporosis worldwide), sarcopenia, loss of functionality and mobility. From around 45-50 years onwards, there is a progressive loss of muscle mass and strength (sarcopenia). This is partially due to an impairment of muscle protein synthesis in response to dietary proteins. Insufficient dietary protein may contribute to age-related loss of lean body mass (LBM) and strength which ultimately affects body movement.

Key ingredients in selected investigational product are:Milk proteins, Calcium, Vitamin D, Vitamin C, Glucosamine Sulfate, Zinc. They have effects to improve physical mobility and functionality. The investigators expect improved effects of a nutritional intervention combined with a physical activity program on mobility in healthy aging subjects with joint discomfort.

Enrollment

55 estimated patients

Sex

All

Ages

45 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Target 45-65 y old
Suffering from (knee) pain. VAS on pain assessment <= 4 on a range 0 to 10
20<BMI<28
Time since menopause above 2y
iPAQ (International Physical Activity Questionnaire) score <600

Exclusion criteria

OA diagnosed
Medicine treatment
Chronic pain killers treatment for more than 7 consecutive days with a washout period of 2 weeks between 2 periods of treatment
Under corticoid, hormone (adrenal, thyroid) treatment
Traditional herbal medicine: in particular with claims on strengthening tendons and bones. This point will be included in FFQ (see annex) and evaluate.

Subjects with chronic tablets supplementation ( calcium or drinking milk over 5 day wk-1 will be excluded, vitamin D, GS, or any with effect on bone and joints ) (set up a FFQ to specially investigate intakes of calcium tablets, milk and animal foods)

Pregnancy
Subject with knee/joint surgery/replacement and CLA (Cross Ligament) injury
History of relevant digestive disease, organic disease of heart, liver or kidney, severe function disorder of liver or kidney, metabolic/endocrine , neurological disease (e.g., Parkinson disease, stroke) with residual impairment, vertigo
Anaemia
Unable to carry out functional tests and questionnaires correctly (KOOS, physical activity)
Lower or upper extremity surgery or fracture in the last 3 months
Currently participating or having participated in another clinical trial in the three previous months