Moxibustion for Diarrhea-predominant Irritable Bowel Syndrome

Shanghai Institute of Acupuncture, Moxibustion and Meridian

Status: Completed

Conditions: Irritable Bowel Syndrome

Treatments: Device: Sham moxibustion; Device: moxibustion

Study type: Interventional

Funder types: Other

Identifiers

NCT02421627

ZYS2015-01

Details and patient eligibility

About

To observe the safety and efficacy of moxibustion on diarrhea-predominant irritable bowel syndrome and evaluation by Magnetic Resonance Imaging (MRI), Event related potential (ERP).

Full description

1. A randomized controlled trial
2. Moxibustion treatment, sham control
3. To observe the safety and efficacy of moxibustion treatment versus placebo control
4. Evaluation by intestinal microbial structural and diversity changes using 16S rDNA sequencing
5. Evaluation by structural MRI and resting state-functional MRI
6. Evaluation by ERP

Enrollment: 104 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Diarrhea-predominant IBS patients who met the Rome III diagnostic criteria;
2. Age 18-65 years old, male or female;
3. Volunteered for the trial, signed the informed consent

Exclusion criteria

1. Intestinal organic disease;
2. Constipation-predominant IBS;
3. Alternating diarrhea and constipation IBS;
4. Unstructured IBS;
5. At the same time, application of smecta, dicetel, cisapride or traditional Chinese medicine;
6. Combined liver, kidney, heart or mental disease patients;
7. Pregnant or lactating women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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104 participants in 2 patient groups

Moxibustion group

Experimental group

Description:

Receiving moxibustion treatment

Treatment:

Device: moxibustion

Sham moxibustion group

Sham Comparator group

Description:

Receiving sham moxibustion.

Treatment:

Device: Sham moxibustion