mPATH for Low-income Older Adults

Johns Hopkins University

Status: Enrolling

Conditions: Cognitive Decline; Insomnia; Sedentary Time

Treatments: Other: Attention Control; Behavioral: mPATH

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT05935241

1R01AG080613-01A1 (U.S. NIH Grant/Contract)

IRB00396390

Details and patient eligibility

About

Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in low-income older adults. The study aims to test the immediate and sustaining efficacy of an mHealth-facilitated Physical Activity Toward Health (mPATH) intervention on cognitive function and sleep in low-income older adults.

Full description

Low-income older adults (LIOA) are a population at higher risk to develop Alzheimer's disease and related dementias (ADRD) and sleep disturbances. Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in LIOA. The growing wearable device and mobile Health (mHealth) provide an innovative approach to deliver individually tailored physical activity interventions at home with flexible schedules to overcome barriers to physical activity in LIOA. In addition, limited research has examined if physical activity interventions impact the individual's Amyloid/Tau/ Neurodegeneration (ATN) Alzheimer's disease biological state and whether physical activity may promote cognition through impacting sleep and AD pathology. This randomized controlled trial is designed to examine the immediate and sustaining efficacy of an mHealth-facilitated Physical Activity Toward Health (mPATH) intervention on cognitive function and sleep in LIOA. mPATH is a personalized physical activity intervention that includes personalized physical activity plans and training sessions, exercise at home by following personalized exercise videos, and biweekly phone coaching over 24 weeks, supported by wearable devices-enabled mHealth strategies. mHealth strategies and exercise videos will be used to support participant's physical activity during 6-12months.

Enrollment: 176 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• self-reported difficulty of sleep
• lack of physical activity/exercise
• low household income
• capacity for moderate intensity exercise

Exclusion criteria

• untreated sleep apnea
• severe depression or anxiety
• dementia
• history of neurologic or psychiatric disorders, neurodevelopmental impairment, traumatic brain injury
• current enrollment in another clinical trial

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

176 participants in 2 patient groups

mPATH

Experimental group

Description:

mPATH is a personalized physical activity intervention that includes personalized physical activity plans and training sessions, exercise at home by following personalized exercise videos, and biweekly phone coaching over 24 weeks, supported by wearable devices-enabled mHealth strategies. mHealth strategies and exercise videos will be used to support participant's physical activity during 6-12months

Treatment:

Behavioral: mPATH

Education and Social control

Active Comparator group

Description:

This attention control group is designed to match the intervention for mPATH's staff-subject interaction duration through monthly home visits in the first 6 months

Treatment:

Other: Attention Control