MPP Narrow QRS:Pilot Study on Multipoint Pacing in Patients With QRS Beetwen 100 and 130 Msec

Humanitas Hospital, Italy

Status

Unknown

Conditions

Heart Failure

Treatments

Device: Implantable cardioverter-defibrillator (ICD)

Device: MultiPoint Pacing ON

Study type

Interventional

Funder types

Other

Identifiers

NCT02402816

1.0

Details and patient eligibility

About

The purpose of this study is to assess the impact of the Multi Point Pacing (MPP) feature in the treatment of patients with QRS beetwen 100 and 130 msec in patients candidate to ICD implant.

Enrollment

50 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients with EF < 35% on OPT at least 3 months and candidate to ICD
QRS duration: 100-130 ms
Patients willing and able to comply with study requirements
Must indicate their understanding of the study and willingness to participate by signing an appropriate informed consent form
Successful quadripolar LV lead implant (only for Treatment Group)

Exclusion criteria

Myocardial Infarction, unstable angina within 40 days prior the enrollment
Patients with no left ventricular contractile reserve after low dose dobutamine stress echocardiography test
Recent cardiac revascularization (PTCA, Stent or CABG) in the 4 weeks prior to enrollment or planned for the 3 months following
Cerebrovascular Accident (CVA) or Transient Ischemic Attack (TIA) in the 3 months prior the enrollment
Primary valvular disease
Unable to comply with the follow up schedule
Less than 18 years of age
Pregnant or are planning to become pregnant during the duration of the investigation
Classification of Status 1 for cardiac transplantation or consideration for transplantation over the next 12 months
Undergone a cardiac transplantation
Life expectancy < 12 months
Patients with permanent Atrial fibrillation
Patients with Nyha 1