MPV and NLR as Predictors of SBP Diagnosis

Sohag University

Status: Completed

Conditions: Spontaneous Bacterial Peritonitis

Treatments: Diagnostic Test: Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)

Study type: Observational

Funder types: Other

Identifiers

NCT04775420

Soh-Med-21-02-22

Details and patient eligibility

About

The aim of the study is to investigate the clinical utility of mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) as diagnostic markers for spontaneous bacterial peritonitis (SBP).

Enrollment: 332 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Decompensated liver cirrhosis ascetic patients.

Exclusion criteria

• Immunocompromised patients.
• Patients who had received antibiotics before hospital admission.
• Patients on anticoagulant medications, NSAIDs, or oral contraceptive drugs.
• Patients with heart failure, diabetes mellitus, hypertension, hyperlipidemia, peripheral vascular disease, hematological disorders, and neoplastic disorders and patients with clinically overt hypothyroidism or hyperthyroidism or with clinically and laboratory-evident autoimmune diseases.

Trial design

332 participants in 2 patient groups

Group 1

Description:

Ascetic patients without spontaneous bacterial peritonitis

Treatment:

Diagnostic Test: Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)

Group 2

Description:

Ascetic patients with spontaneous bacterial peritonitis

Treatment:

Diagnostic Test: Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)