MR-Evaluation of Renal Function in Anesthetized Pediatric Patients (MERAPED)

Uppsala University

Status and phase: Not yet enrolling; Phase 4

Conditions: MRI; Renal Oxygenation; Renal Blood Flow; Anesthesia

Treatments: Drug: Anesthesia Maintenance Agent

Study type: Interventional

Funder types: Other

Identifiers

NCT06876870

MERAPED

2025-520627-25-00 (EU Trial (CTIS) Number)

Details and patient eligibility

About

The goal of this study is to investigate the effect of the anesthetic agents sevoflurane or propofol on the blood flow and oxygen delivery to the kidneys.

Pediatric patients who are planned to undergo an MRI scan with generalized anesthesia will be randomized to either IV anesthesia with propofol or inhalation anesthesia with sevoflurane. Both of these anesthetic methods are commonly used for anesthesia on an everyday basis.

In addition to the clinically indicated MRI, Multiparametric MRI will be performed to visualize the effect of the anesthetic agent on renal blood flow, perfusion and oxygenation.

Full description

See the study protocol

Enrollment: 50 estimated patients

Sex: All

Ages: 1 month to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pediatric Patients (1 month -14 years of age)
• Indicated for MRI with anesthesia
• ASA (American Society of Anesthesiologists) physical status I-III

Exclusion criteria

• Known renal impairment or chronic kidney disease
• Severe cardiac or pulmonary disease
• Allergy to either Propofol or Sevoflurane
• Contraindications to Magnetic Resonance Imaging
• Contraindications to either Propofol or Sevoflurane
• Declined participation or declined consent from patients, parents or guardians
• Ongoing acute kidney injury

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Propofol

Active Comparator group

Description:

Propofol Maintenance Anesthesia

Treatment:

Drug: Anesthesia Maintenance Agent

Sevoflurane

Active Comparator group

Description:

Sevoflurane Maintenance Anesthesia

Treatment:

Drug: Anesthesia Maintenance Agent