MR-Evaluation of Renal Function In Septic Patients (MERSEP)

Uppsala University

Status: Completed

Conditions: COVID-19; Acute Kidney Injury; Sepsis, Severe

Treatments: Other: Plasma expansion with Ringer's Acetate

Study type: Interventional

Funder types: Other

Identifiers

NCT02765191

MERSEP-523-2014-2569

Details and patient eligibility

About

A study of renal blood flow and renal oxygenation measured by magnetic resonance after a standardized fluid challenge in critically ill, resuscitated, patients with sepsis due to COVID-19 or other agents.

Full description

Critically ill, septic patients with or without acute kidney injury (AKI) above 18 years of age who have been circulatory and respiratory stabilized will be screened for inclusion.

After the patients have been adequately treated with antimicrobial agents, source control and circulatory and respiratory stabilized, the patient will be moved to the Magnetic resonance imaging (MRI)-suite and placed in the MRI-camera. We plan to, at the same time, study renal blood flow (RBF) and oxygenation with 4 different MRI techniques; arterial spin labeling (ASL), Blood oxygen level dependent (BOLD)-technique, T(2) -Relaxation-Under-Spin-Tagging (TRUST) and Phase contrast at two conditions;

1. at baseline after stabilization
2. after intravenous infusion of 7,5 ml/kg mL Ringer's acetate

The following data will be registered:

1. Age, gender, length and weight,
2. concomitant diseases and treatment,
3. present disease and treatment,
4. source of admission - emergency department or ordinary ward,
5. daily laboratory reports,
6. results from other investigations, e.g. x-rays, cultures etc.,
7. recordings from the intensive care unit (ICU) monitors
8. Continuous renal replacement therapy (CRRT) - duration type, flow rate, replacement fluid, etc.
9. dead or alive at discharge and 90 days mortality,
10. renal function at discharge,
11. treatment restrictions,
12. if the patient has died, the results from a possible postmortem examination. As well as all data obtained during the MRI-examination.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with clinical diagnosis sepsis (infection and organ dysfuncion) treated in intensive care.
• Manifest Acute kidney injury (AKI) or risk of AKI.
• 18 years of age or older

Exclusion criteria

• Pregnancy
• Chronic kidney failure
• Renal Replacement Therapy
• Instability in vital parameters to a degree where MRI is not feasible
• Contraindications for MRI (implants, coils, pacemakers, etc)

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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22 participants in 1 patient group

Study group

Experimental group

Description:

Subjects investigated according to protocol after administration of bolus of Ringer's Acetate

Treatment:

Other: Plasma expansion with Ringer's Acetate