MR Imaging of Knee Osteoarthritis and Acute Knee Injuries

University of California San Francisco (UCSF)

Status

Completed

Conditions

Osteoarthritis, Knee

Treatments

Procedure: Total Knee Replacement

Procedure: Cartilage Resurfacing Surgery

Procedure: ACL Reconstruction Surgery

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT00504114

2R01AR046905

Details and patient eligibility

About

The purpose of this study is to use better magnetic resonance imaging (MRI) techniques to examine the knee and the bony and soft tissue changes so as to better predict the progression of osteoarthritis and acute knee injuries.

Full description

The study will examine the pathophysiology of bone marrow changes, relationship between trabecular bone and cartilage changes; and evaluate T1p relaxation methods and its' relating to cartilage loss. The protocol is geared towards sequences utilizing 3 Tesla magnetic resonance imaging (MRI) that will enable the measures of cartilage volume and T2. Measures cartilage volume and T2 are more established MR methods for studying osteoarthritis (OA).

All OA and Anterior cruciate ligament (ACL) subjects will undergo MR imaging of the knee joint at 3 Tesla at baseline,, and three annual follow up time points. Regions of interest will include the total tibial and femoral cartilage, and sub-division such as the medial and lateral compartments of the tibial and femoral cartilage to account for localized disease activity and progression.

Bone marrow edema size, MR spectroscopy based marrow fat/water content, and trabecular bone microarchitecture underlying the edema will be measured in the OA and ACL groups to determine whether there is any distinction between these measures in OA and in traumatic ACL injury, cross-sectionally and longitudinally, and their relation to cartilage loss and OA progression.

Enrollment

139 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy volunteers will have had no previous knee symptoms or surgery
Patients with mild arthritic symptoms and Kellgren Lawrence score of 2
Patients with severe arthritic symptoms and Kellgren Lawrence score of 3, or 4
Patients with acute ACL injury with associated bone contusion and bone edema
Patients with posttraumatic knee injury or degenerative condition and will have cartilage resurfacing procedures
Patient is willing to participate in the proposed study as evidenced by providing written informed consent.

Exclusion criteria

Current use of an investigational drug
Conditions other than OA which limit lower extremity function and mobility and/or would confound the evaluation of function (e.g., clinically significant spinal disc degeneration, painful or dysfunctional feet, peripheral vascular disease, lumbar radiculopathy or a stroke.)
Patients with metallic fragments in the eyes, vascular clips, pacemakers, and other contraindications to MRI