MRI-based Biomarkers for Predicting Punctate White Matter Lesions in Neonates (PWML)

Xi'an Jiaotong University

Status: Unknown

Conditions: Cerebral Palsy; Amblyopia; Brain Damage, Chronic; Brain Diseases

Study type: Observational

Funder types: Other

Identifiers

NCT02637817

2016YFC0100300

Details and patient eligibility

About

As a common white matter (WM) disease in preterm neonates, punctate white matter lesion (PWML) frequently leads to the abnormalities of brain development (e.g. the motor, visual and auditory disorders), even to cerebral palsy (CP) and amblyopia during childhood. However, it is lack of certain methods in identifying the prognosis of PWML. Through using various advanced MRI techniques, neuro-behavioral and visual assessments, a multicenter longitudinal study would be conducted to follow-up the PWML neonates with varying spatial-position and degree lesions. Through tracking the variations in WM microstructures from neonate period to childhood (2 years old and 3 years old), this study aims to explore (1) the potential relations between varying PWMLs and motor and visual disorders (2) the relations between WM MRI-metrics and neurodevelopmental assessment results, and thus determine the early biomarkers to identify CP and amblyopia.

Enrollment: 600 estimated patients

Sex: All

Ages: 1 to 28 days old

Volunteers: No Healthy Volunteers

Inclusion criteria

-(1) Age: 1-28 days (2) PWML (3) High quality MRI scan

Exclusion criteria

-(1) Congenital malformations, infections, metabolic disorders, intraventricular hemorrhage (2) Neonates of mothers with gestational diabetes, hypertension, hypoglycemia and history of alcohol

Trial design

600 participants in 2 patient groups

Control Group

Description:

Neonates with no evidence of brain lesions on conventional MRI.

Patients Group

Description:

Neonates with PWML diagnosed by conventional MRI.