MRI-based Signatures for Survival Prediction in Cervical Cancer With Radiotherapy

Fujian Provincial Cancer Hospital

Status: Not yet enrolling

Conditions: MRI; Prognostic Model; Radiotherapy; Cervical Cancer

Treatments: Radiation: Treatment mainly composed of external pelvic beam radiotherapy (EBRT) followed by individualized high-dose-rate intracavitary brachytherapy (HDR-ICBT) .

Study type: Observational

Funder types: Other

Identifiers

NCT06197126

SY-GO001

Details and patient eligibility

About

This study aims to validate the value of tumor involvement features based on MRI in cervical cancer, facilitate the development of a more appropriate model for risk stratification, and help patients with varying risk profiles make appropriate decisions in treatment selection and follow-up plans.

Full description

Even with the development of advanced technology, the prognosis for CC patients who received radiotherapy is still an intractable problem. Almost 40% suffered disease recurrence among locally advanced patients after radiotherapy and the reported 5-year overall survival is 50-70%. The present FIGO staging is controversial in pre-treatment assessment, which is mainly based on physical examination. An ambiguous diagnosis leads to different treatment strategies and follow-up plans, which is associated with prognosis non-improvement. Incorporation of the tumor involvement features based on the MRI into pre-treatment assessment could standardize and improve the consistency and repeatability of diagnosis.

Enrollment: 200 estimated patients

Sex: Female

Ages: 20 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• (1) pathologically confirmed CC, (2) initially treated in our center

Exclusion criteria

• (1) lack of pre-treatment MRI, (2) prior anti-tumor treatment, (3) pelvic surgery history, (4) incomplete therapy, (5) loss of follow-up

Trial design

200 participants in 1 patient group

cervical cancer patients with radiotherapy

Description:

Radiotherapy is the main treatment strategy with an overall dose of over 75Gy.

Treatment:

Radiation: Treatment mainly composed of external pelvic beam radiotherapy (EBRT) followed by individualized high-dose-rate intracavitary brachytherapy (HDR-ICBT) .