MRI-based Synthetic CT Images of the Head and Neck

Amsterdam UMC, location VUmc

Status: Completed

Conditions: Imaging of Bony Structures of the Head (Various Conditions); Hearing Loss; Cholesteatoma; Head and Neck Tumor; Sinusitis

Treatments: Diagnostic Test: CT scan; Diagnostic Test: MRI scan; Other: Synthetic CT scan

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT06016335

NL80426.029.22 (Registry Identifier)

2022.0234

Details and patient eligibility

About

In case of surgical procedures in the head and neck region, MRI in combination with CT of the bone is often the standard modality to visualise bony landmarks for planning, navigation and risk assessment. An important downside of a CT scan is the associated radiation exposure, especially in children. An additional downside is the sedation or general anaesthesia needed for both the MRI and CT scan session in very young children. These downsides could be removed if the CT scan can be substituted by an MRI sequence that can provide the same information as CT. This project aims to determine the feasibility of recreating CT like images of the craniofacial bones from MRI images using machine learning techniques.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients from the outpatient ENT (Ear, Nose, Throat)-clinic.
• Aged 18 years or older.
• Referred for CT scan of the mastoid, sinonasal complex or face.

Exclusion criteria

• Pregnancy.
• Contra-indications for MRI or CT.
• Unwillingness to be informed about possibly clinically relevant, incidental findings from the MRI examination.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

Training

Other group

Description:

Data from 25-35 participants will be used to train an algorithm to generate synthetic CT images from MRI scans.

Treatment:

Diagnostic Test: CT scan

Diagnostic Test: MRI scan

Testing

Other group

Description:

Data from remaining participants will be used to test the synthetic CT algorithm, by comparing true CT scans to synthetic CT scans made from MRI.

Treatment:

Diagnostic Test: CT scan

Diagnostic Test: MRI scan

Other: Synthetic CT scan