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MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders

University of Zurich (UZH) logo

University of Zurich (UZH)

Status

Enrolling

Conditions

Spinal Injury

Study type

Observational

Funder types

Other

Identifiers

NCT02170155
KEK-ZH-2012-0343/PB_2016-00623

Details and patient eligibility

About

Understanding the onset and progression of spinal cord disorders is an important aim in clinical neurology. An early diagnosis with consequent therapy might prevent the progression of disability. Therefore, we aim to determine structural and dynamic changes in the microstructure of the spinal cord and CSF, and to explore the relationships between the MRI parameters, clinical disability, and electrophysiology.

In some patients that undergo decompressive surgery CSF pressure will be measured invasive perioperative for 24h to find out if functional limitations and structural changes correlate with the spinal pressure and the spinal perfusion when the spinal cord is damaged.

Enrollment

350 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Cervical injury
  • Informed consent
  • Age 18-80
  • CSM

Exclusion criteria

  • No other neurologic disorder and psychiatric disorder
  • Seizure
  • MRI incompatibility
  • Pregnancy

Trial design

350 participants in 3 patient groups

Patients with CSM
Patients with spinal injury (SCI)
Healthy controls

Trial contacts and locations

1

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Central trial contact

Patrick Freund, PhD

Data sourced from clinicaltrials.gov

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