MRI in Diagnosing and Monitoring CIDP

University of Aarhus

Status: Completed

Conditions: Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Study type: Observational

Funder types: Other

Identifiers

NCT02017769

2012-100

Details and patient eligibility

About

We want to study whether MRI can be useful in diagnosing and monitoring patients with CIDP in maintenance treatment with immunoglobulin

Full description

Chronic inflammatory neuropathies such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) can be successfully treated with immunoglobulin either intravenously (IVIG) or subcutaneously (SCIG).

CIDP is diagnosed by electrophysiology which is time-consuming and unpleasant for the patient.

New techniques suggest that Magnetic Resonance Imaging (MRI) and ultrasound imaging can be used to detect injuries in the peripheral nerves

We want to study if MRI and ultrasound is able to detect damages in peripheral nerves, nerve roots and plexus in patients with CIDP.

Moreover, we want to compare these findings to healthy matched controls and to see if treatment with immunoglobulin changes findings in MRI

Enrollment: 39 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

CIDP patients

• Age > 18 and < 80 years
• Diagnosed with definite and probable CIDP and fulfilling the European Federation of Neurological Sciences/Peripheral Nerve Society (EFNS/PNS) criteria

Healthy controls

• Age > 18 and < 80 years
• No neurological disorders

Exclusion criteria

• Age < 18 or > 80 years
• Contraindications to MRI
• Pregnancy
• Other cause of neuropathy (incl. pressure neuropathy)
• Diabetes mellitus

Trial design

39 participants in 3 patient groups

CIDP - treated

Description:

Patients diagnosed with CIDP and fulfilling the criteria by EFNS and PNS and in maintenance treatment with subcutaneous immunoglobulin

Healthy controls

Description:

Healthy, gender and age matched controls

CIDP - untreated

Description:

Patients newly diagnosed with CIDP and untreated are treated with immunoglobulin and re-examined after 4 months of treatment