MRI Maker of Perioperative Neurocognitive Disorder (MRIPND)

Shanghai Jiao Tong University

Status: Unknown

Conditions: Necrosis of Femoral Head; Fracture of Lower Limb; Knee Osteoarthritis

Study type: Observational

Funder types: Other

Identifiers

NCT03773627

2017-075

Details and patient eligibility

About

Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear. Moreover, valid biomarkers for the prediction or diagnosis of the development of delayed neurocognitive recovery in aged patients have not been identified so far. The purpose of this study is trying to find the functional MRI marker of PND.

Enrollment: 100 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 60 years
• Spoke proficient Chinese
• Selected to lower limb osteopathic surgery
• Informed consent signed by the patient
• Underwent general anesthesia

Exclusion criteria

• Existing cerebral disease, or have a history of neurological and psychiatric diseases including AD, stroke, and psychosis
• Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
• Several audition or vision disorder
• With standard contraindications to MRI examinations
• Unwillingness to comply with the protocol or procedures.