MRI-markers to Monitor Small Vessel Disease Dynamics in the Prognosis of Small Vessel Disease-associated, Cerebrovascular Events (MRI-PRO-SVD)

Insel Gruppe AG, University Hospital Bern

Status: Enrolling

Conditions: CAA - Cerebral Amyloid Angiopathy; Cerebral Small Vessel Diseases; Intracerebral Hemorrhage

Treatments: Diagnostic Test: Combined 3- and 7 Tesla-MRI

Study type: Observational

Funder types: Other

Identifiers

NCT05773235

2021-02006

Details and patient eligibility

About

This is a nested cohort study in the PRO-SVD cohort. Small vessel disease is a chronic disease and is thought to progress over time. MRI is the gold standard to diagnose small vessel disease, but data on MRI-visible disease progression are scarce. Complications of small vessel disease as well as location pattern, distribution and severity of these MRI small vessel disease markers differ according to the underlying phenotype. The primary aim of this project is to investigate individual small vessel disease burden progression detected by MRI in survivors or intracerebral hemorrhage.

Enrollment: 60 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

For patients with intracerebral hemorrhage

Inclusion Criteria:

• Patient participating in the PRO-SVD cohort
• Symptomatic intracranial hemorrhage
• Written informed consent provided by patient or next-of-kin
• No contraindications against MRI

Exclusion Criteria:

• Patient unsuitable for MRI follow-ups (e.g. claustrophobia)
• Patients unlikely to attend 1-year follow-up

For healthy controls

Inclusion Criteria:

• Clinically healthy person ≥ 55 years
• Written informed consent provided by the healthy control
• No contraindications against MRI

Exclusion Criteria:

• Known or suspected cerebral small vessel diseases or presence of concurrent diseases potentially mimicking small vessel disease (e.g. multiple sclerosis, previous heart surgery etc.)
• Pre-existing dementia, cognitive decline or disorder of the central nervous system.

Trial design

60 participants in 2 patient groups

Patients with intracerebral hemorrhage

Description:

Patients with symptomatic intracranial hemorrhage (defined as non-traumatic intracerebral hemorrhage or convexity, non-aneurysmal subarachnoid hemorrhage) enrolled in the PRO-SVD study

Treatment:

Diagnostic Test: Combined 3- and 7 Tesla-MRI

Healthy controls

Description:

Clinically healthy persons of at least 55 years of age

Treatment:

Diagnostic Test: Combined 3- and 7 Tesla-MRI