MRI of the Chest Under High Frequency Ventilation

Lausanne University Hospital (CHUV)

Status: Completed

Conditions: Non-invasive Ventilation; Healthy Volunteer; High-frequency Ventilation

Treatments: Other: MRI without High-frequency non-invasive ventilation; Device: MRI with High-frequency non-invasive ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02973373

MR-HFV

Details and patient eligibility

About

The purpose of the study is to evaluate the benefit on image quality of MRI of the chest performed under high frequency non-invasive ventilation. This technique indeed allows to generate an apnea duration of several minutes with acquisitions performed at full inspiration. This study will be applied on healthy subjects.

Full description

High frequency ventilation (HF-V) has been applied by using a non-invasive interface allowing to obtain a prolonged apnea in awaken subjects. Such an application should be of interest for MRI taking into account its susceptibility to motion of the chest and the imperfect techniques of respiratory gating that are usually performed at end expiration. The purpose of this study is to assess the benefit on image quality of different sequences performed with and without the device in healthy subjects.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjets : normal respiratory function and no known lung disease
• Age >=18y

Exclusion criteria

• Pregnancy

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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10 participants in 2 patient groups

MRI with HF-NIV

Experimental group

Description:

Intervention: Acquisition of MRI with High-Frequency non-invasive ventilation (HF-NIV)

Treatment:

Device: MRI with High-frequency non-invasive ventilation

MRI without HF-NIV

Active Comparator group

Description:

Intervention: MRI without High-Frequency non-invasive ventilation (HF-NIV)

Treatment:

Other: MRI without High-frequency non-invasive ventilation