MRI Perfusion in Adnexal Masses (MRI-CAM)

Assiut University

Status: Completed

Conditions: Complex Adnexal Masses

Treatments: Device: MRI perfusion

Study type: Observational

Funder types: Other

Identifiers

NCT02694406

MRI-CAM

Details and patient eligibility

About

As ovarian cancer is characterized by an anarchic neovascularization resulting in a wide number of immature microvessels. These vessels are characterized by a lack of coverage by pericytes and the higher expression of one of the receptors of Vascular Endothelial Growth Factor on both endothelial and epithelial cells of ovarian cystadenocarcinomas. These physio pathogenic characteristics have been demonstrated to be in line with variations of MR perfusion parameters.

Unlike many lesions that occur in other parts of the body, biopsy should not be performed in adnexal masses that demonstrate no evidence of peritoneal disease because it may cause spillage of cystic contents, potentially leading to iatrogenic up-staging of what may have been a malignant tumor that was limited.

Enrollment: 40 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• complex adnexal mass
• patient fit for surgery

Exclusion criteria

• any general contraindication to MRI
• severely ill patients
• those with claustrophobia.