MRI Perfusion on T1 and T2 Brain Lesion(s) (METAPERF)

University Hospital, Lille

Status

Completed

Conditions

Lung Carcinoma Metastatic to the Brain

Treatments

Other: MRI T1 T2 sequences

Study type

Interventional

Funder types

Other

Identifiers

NCT02250755

2012_27

2012-A01644-39 (Other Identifier)

Details and patient eligibility

About

This study therefore aims to assess current treatment recommended by scientific societies [ 6-13 ] , brain MRI with injection of contrast for the diagnosis and monitoring of brain metastases . The recommended dose of this examination gadolinium is from 0.1 to 0.3 mmol / kg [ 14 ] . Sequences infusion different from one center to the other made : some use the infusion T1, other infusion T2 * . No recommendation establishes whether it is preferable to use one or the other of these sequences.

No examination is added for the purposes of protocol. Indications for MRI and the number and timing of MRI checks under this protocol are consistent with what is done in practice . The used type of gadolinium and the injected dose will be identical for both sequences infusion . The assessment shall not in any case the contrast but the interpretation of the sequence itself. Special procedures monitoring implemented embodiment correspond to the two sequences instead of infusion (one of T1-weighted and T2 * in the other ) , in the original MRI and MRI of the first control , in order to compare their effectiveness

Full description

Eligibility criteria:

Major Patients
Addressed MRI for initial assessment of brain metastases
At a suspicion of one or more brain metastases in the brain scanner routine screening
Follow for lung cancer histologically documented
In the Thoracic Oncology Service Professor Lafitte (contact: Dr Cortot)
To whom treatment with chemotherapy or targeted therapy (including anti-angiogenic) is considered
Be socially insured

Main Outcomes measures:

Comparing the area under the ROC curve of different parameters evaluated in T1 and T2 * perfusion during the initial assessment for the diagnosis of maximal tumor response evaluated at 1 year

Enrollment

30 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Major Patients
Addressed to MRI for initial assessment of brain metastases
At a suspicion of one or more brain metastases in the brain scanner routine screening
Followed for lung cancer histologically documented in the Thoracic Oncology Service of Professor Lafitte (contact: Dr Cortot)
To whom treatment with chemotherapy or targeted therapy (including anti-angiogenic) is considered
Be socially insured-

Exclusion criteria

Absolute contraindication to MRI (pacemaker, implantable pacemaker, metallic foreign body intraorbital)
Patients minors under guardianship / curatorship
Patients with impaired judgment skills or unable to receive information
Pregnant Women
Patients for which lesions are not compatible with lung metastases
Patients with brain metastases or already known and explored MRI
Patients for whom treatment by surgical excision of brain metastases is considered