MRI & QST Analysis in Trigeminal Neuralgia and Persistent Idiopathic Facial Pain

Walton Centre NHS Foundation Trust

Status: Active, not recruiting

Conditions: Facial Pain

Treatments: Other: Quantitative Sensory Testing

Study type: Observational

Funder types: Other

Identifiers

NCT05147454

RG447-21

Details and patient eligibility

About

Patients with a definite diagnosis of classical TGN and PIFP will undergo a structured clinical questionnaire and a trigeminal sensory profile using the quantitative sensory testing. Clinical measures and sensory profiles will be correlated with MRI measures.

Full description

Patients with a definite diagnosis of classical TGN and PIFP (according to the 2020 ICOP Classification) will undergo a structured clinical questionnaire and a trigeminal sensory profile using the quantitative sensory testing. Clinical measures and sensory profiles will be correlated with the presence and the geometry of neurovascular compression at MRI. Moreover quantitative structural neuroimaging analysis, such as trigeminal root volume, will be performed in each patient and correlated with clinical and QST data.

Enrollment: 40 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Definite diagnosis of Classical or Idiopathic Trigeminal Neuralgia or Persistent Idiopathic Facial Pain according to the latest ICOP 2020 Criteria
• Naive to any surgical procedures

Exclusion criteria

• Any major chronic painful or other neurological disease
• Diagnosis of Secondary Trigeminal Neuralgia
• Diagnosis of other facial pain syndromes
• Cognitive disturbances

Trial design

40 participants in 2 patient groups

Trigeminal Neuralgia

Description:

Patients with a definite diagnosis of Classical or Idiopathic Trigeminal Neuralgia

Treatment:

Other: Quantitative Sensory Testing

Persistent Idiopathic Facial Pain

Description:

Patients with a definite diagnosis of Persistent Idiopathic Facial Pain

Treatment:

Other: Quantitative Sensory Testing