mRNA Expression and Genetic Polymorphisms Affecting DRD3 (rs6280) and HTR2A (rs6313) in Bruxism

University of Monastir

Status: Not yet enrolling

Conditions: Bruxism

Treatments: Genetic: Genetic polymorphism

Study type: Observational

Funder types: Other

Identifiers

NCT06457646

0000-0002-5945-7764 (Other Identifier)

011/2021

Details and patient eligibility

About

The goal of this observational study is to learn about the genetic factors influencing bruxism, a condition characterized by teeth grinding, in a group of participants. The main questions it aims to answer are:

• Is there a significant association between the rs6313 polymorphism of the HTR2A gene and bruxism?
• Is there a significant association between the rs6280 polymorphism of the DRD3 gene and bruxism?

Participants will:

Provide DNA samples for genotyping of the DRD3 (rs6280) and HTR2A (rs6313) polymorphisms.

Provide RNA samples to assess changes in the expression of HTR2A and DRD3. Researchers will compare the genetic data and RNA expression levels between individuals with bruxism and those without (controls) to see if there are significant genetic differences and expression changes associated with bruxism.

Enrollment: 169 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• be above 18 years of age and have a confirmed diagnosis of bruxism

Exclusion criteria

• Systemic diseases,
• orofacial dysfunction,
• acute symptoms such as neurodegenerative diseases (specifically Parkinsons disease),
• Taking medication such as anxiolytics