MRS and 11C-methionine PET/CT in the Diagnosis of Glioma

Fudan University

Status: Completed

Conditions: Glioma

Treatments: Other: tumors are confirmed by surgery and pathology

Study type: Interventional

Funder types: Other

Identifiers

NCT03009318

81171295

Details and patient eligibility

About

MET PET and MRS are often performed as imaging tool for the differential diagnosis of gliomas. But both techniques have limitations causing misdiagnosis; thus, the investigators tried to combine these two imaging tools to study whether the combination of MET PET and MRS could raise the diagnosis ability of the radiological diagnosis of gliomas.

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with non-enhancing supratentorial lesions shown by contrast-enhanced MRI
2. No surgery, chemotherapy or radiotherapy history
3. All patients gave written informed consent.

Exclusion criteria

1. Patients with infratentorial Neoplasms
2. Patients with enhancing supratentorial lesions
3. Recurrent gliomas after surgery
4. Primary gliomas with history of radiotherapy or chemotherapy
5. History of malignant tumours at any body site
6. Inability to give informed consent

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

MRS imaging and 11C-MET PET/CT

Other group

Description:

Each patient underwent both MRS and MET PET before surgery.

Treatment:

Other: tumors are confirmed by surgery and pathology