MS Detection of Somatic Mutations in Hematological Malignancies (MAHM)

University Hospital, Strasbourg, France

Status: Unknown

Conditions: Hematological Malignancy

Study type: Observational

Funder types: Other

Identifiers

NCT03771079

7259

Details and patient eligibility

About

Detection of somatic mutations in hematological malignancies is now routinely assessed by NGS sequencing. This powerful approach is nevertheless time consuming and its costs represent limitation for its availability. An original approach is now available, using mass spectrometry (MS). In this study the analytical performance of both methods will be compared, using samples that were previously analyzed by NGS.

The goal of the study is to assess whether MS can represent or not a faster and cheaper way to detect key point mutations in patients suffering from hematological malignancies

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adults >18 years old
• anonymized samples already studied with NGS in Strasbourg university hematology center for somatic mutations
• non-opposition of the patient for testing the archive sample with the new method

Exclusion criteria

• opposition for testing the archive sample with the new method
• insufficient archival material
• patient under protection