MSCs Therapy for Cerebral Palsy

Aljazeera Hospital

Status: Unknown

Conditions: Stem Cell Transplant Complications

Treatments: Other: stem cells

Study type: Interventional

Funder types: Other

Identifiers

NCT04653077

cerebral palsy

Details and patient eligibility

About

Cerebral palsy (CP) is the most common physical disability in childhood. CP comprises a heterogeneous group of disorders that are the result of a non-progressive disruption or injury that occurred during fetal brain development or within the first two years of life.

Full description

This disruption can result in spasticity, dystonia, muscle contractures, weakness and difficulty in coordination that ultimately affects the ability to control movements. Resultant activity limitations may affect gross motor movements, fine motor movements, speech and communication, as well as eating and drinking.

Enrollment: 50 estimated patients

Sex: All

Ages: 2 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Must be more than 2 year of age and less than 12 years of age at the time of screening for inclusion in the study.

  • Clinical evidence of a non-progressive motor disability due to brain dysfunction.

Exclusion criteria

• • Intractable seizures

  • Traumatic brain injury
  • Genetic disorder
  • Current Infection
  • Renal insufficiency
  • Hepatic disease
  • HIV+ (as demonstrated by positive blood test)
  • Immunosuppression

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

stem cells

Experimental group

Description:

Intravenous and Intrathecal transplantation of specific populations of purified bone marrow-derived stem cells and mesenchymal stem cells.

Treatment:

Other: stem cells