MSG and Gastrointestinal Motility

Gunma University

Status: Completed

Conditions: Gastroesophageal Reflux

Treatments: Dietary Supplement: Monosodium glutamate; Dietary Supplement: Sodium chloride

Study type: Interventional

Funder types: Other

Identifiers

NCT01009658

GU-CT 696

GU-696

Details and patient eligibility

About

The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).

Full description

Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption.

. To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects
• Must not have digestive symptoms
• Must not eat within six hours of study participation

Exclusion criteria

• Regular medications for the gastrointestinal tract
• Previous Helicobacter pylori infection
• Previous abdominal surgery

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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40 participants in 2 patient groups, including a placebo group

MSG first

Active Comparator group

Treatment:

Dietary Supplement: Monosodium glutamate

NaCl first

Placebo Comparator group

Treatment:

Dietary Supplement: Sodium chloride