Mu Opioid Receptor 1 Expression and Activation Patterns in Colorectal Cancer

La Fe University and Polytechnic Hospital

Status: Unknown

Conditions: Colorectal Surgery for Stage II / III Primary Colorectal Cancer

Treatments: Other: Assess the difference in MOR-1 expression between healthy and tumor tissue

Study type: Observational

Funder types: Other

Identifiers

NCT04353882

MOROCCO-II

Details and patient eligibility

About

Observational case-control study in a retrospective cohort of patients with stage II or III colorectal cancer undergoing scheduled surgery.

Full description

Observational case-control study in a retrospective cohort of patients with stage II or III colorectal cancer undergoing scheduled surgery. Period January 2010-December 2014. Patients must have had at least 5 years of follow-up to define disease-free survival. From the cohort of patients previously studied in our center by immunohistochemistry, 31 we will select 10 cases with recurrence by random sampling and we will match 10 controls by leveling the propensity score (propensity score matching).

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over 18 years of age.
• Colorectal surgery scheduled between January 2010 - December 2014.
• Stage II or III colon or rectum neoplasm (T3 / T4 N + M0).

Exclusion criteria

• Neoplasia of colon or rectum in Stage I or Stage IV.
• Non-oncological colorectal surgery.
• Urgent surgery

Trial design

20 participants in 2 patient groups

patients with tumor recurrence

Treatment:

Other: Assess the difference in MOR-1 expression between healthy and tumor tissue

patients with-out tumor recurrence

Treatment:

Other: Assess the difference in MOR-1 expression between healthy and tumor tissue