Mucin Glycosylating Enzymes in Head and Neck Cancers

National Taiwan University

Status: Unknown

Conditions: Glycosyltion Enzymes and Function Abnormalities

Study type: Observational

Funder types: Other

Identifiers

NCT01976377

201307074RIND

Details and patient eligibility

About

Head and neck squamous cell carcinoma(HNSCC) is the fourth common malignancy in Taiwan. It accounts for 5.8% of all cancers and causes 2,463 deaths per year. Aberrant glycosylation is the hallmark of most human cancers, including HNSCC, and affects many cellular properties. This study is aimed at exploring the role of mucin glycosylating enzymes in HNSCC.

Full description

Glycosylation is the most common post-translational modification of proteins. Aberrant glycosylation is the hallmark of most human cancers and affect many cellular properties, including cell proliferation, apoptosis, differentiation, transformation, migration and immune response.

Though widely explored in various human cancers, the role of mucin glycosylating enzymes in HNSCC has not been elucidated. Our aims is to analyze the expression patterns of mucin glycosylating enzymes in HNSCC tissues. Furthermore, we will correlate the expression levels of mucin glycosylating enzymes with clinical characteristics of HNSCC patients.

Enrollment: 200 estimated patients

Sex: All

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Head and neck cancer patients receiving operation in National Taiwan University Hospital

Exclusion criteria

• Recurrence or non-operable patients

Trial design

200 participants in 1 patient group

Stage I, II, III, IV HNSCC

Description:

Stage I, II, III, IV HNSCC reveive treatment in NTUH