Mucosal-Associated Invariant T Cells in Cases of Miscarriage

Assiut University

Status: Completed

Conditions: Miscarriage

Treatments: Diagnostic Test: MAIT cells

Study type: Observational

Funder types: Other

Identifiers

NCT04492098

MAIT-RPL

Details and patient eligibility

About

Miscarriage is the most frequently encountered complication of pregnancy ranging from 10% to 30%. The etiology of recurrent spontaneous miscarriage (RSM) in 40%-50% of cases cannot be identified. Immunological disturbances have been suggested to play an important role.

Previous studies have focused that women with miscarriage have elevated NK cell numbers and activity both in the periphery and in the endometrium. Also, NK cells in women with RSM displayed an imbalance of Killer cell Ig-like receptors (KIRs) in favor of activating KIR leading to an unbalanced activation of dNK cytotoxicity and higher risk of miscarriage.

Enrollment: 50 patients

Sex: Female

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Regular marital life with the same partner.
• Regularly menstruating before current pregnancy.
• Spontaneous conception.

Exclusion criteria

• Women with Polycystic ovarian syndrome or any endocrinal abnormalities like DM, thyroid disorders.
• History of abnormal uterine cavity proved by sonohysterography or hysteroscopy before pregnancy.
• Women with positive consanguinity.

Trial design

50 participants in 1 patient group

study group

Description:

women with spontaneous miscarriage

Treatment:

Diagnostic Test: MAIT cells