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Mucosal Innate Immune Activation in Chronic Intestinal Disorders

University of Arkansas logo

University of Arkansas

Status

Withdrawn

Conditions

Irritable Bowel Syndrome
Inflammatory Bowel Diseases

Treatments

Procedure: Biopsies from endoscopy

Study type

Observational

Funder types

Other

Identifiers

Details and patient eligibility

About

Crohn's disease and ulcerative colitis are types of chronic intestinal disorder called inflammatory bowel diseases (IBD) that can affect the small and large bowel causing symptoms of abdominal pain, diarrhea, blood in the stool, and weight loss. Irritable bowel syndrome (IBS) is a milder form of IBD, with symptoms of abdominal pain, bloating, diarrhea or constipation, and blood in the stool. It is not known what causes diseases such as IBD and IBS. This study will look at the events in the gut that leads to leaky gut and inflammation in patients with IBD and IBS. The study will also see if medications such as rifaximin and mesalamine may reduce the amount of leaky gut.

Sex

All

Ages

18 to 99 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Men and women, 18-years old and older
  • Presenting at the University of Arkansas for Medical Sciences (UAMS) Endoscopy center to undergo endoscopy with biopsy for surveillance, screening or diagnosis.

Exclusion criteria

  • Subjects classified in an anesthesia risk group , American Society of Anesthesiologists Class (ASA) ≥ 4,
  • history of bleeding diathesis or coagulopathy
  • stroke or transient neurological attack within the last 6 months
  • pregnancy
  • currently on blood thinners (excepting aspirin)
  • subject is unable to consent themselves

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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